Big cats (and other large predators) are perfectly harmless… until they're not.
And then you're likely dead or at least severely maimed.

This is how fast all big cats move:

Wild animals aren't marauding monsters but they aren't cute little plush animals either.
Remember what happened to Grizzly Man…

(Also, there's a big difference between subsistence hunting and trophy hunting.)

Just gonna remind you that a lion is a massive killing machine and if you weren't in that van it wouldn't have a problem disemboweling you. Lions evolved to kill. Humans didn't. That's why we invented guns.